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  • Title: Stereoselective synthesis of chiral α-amino-β-lactams through palladium(II)-catalyzed sequential monoarylation/amidation of C(sp(3) )-H bonds.
    Author: Zhang Q, Chen K, Rao W, Zhang Y, Chen FJ, Shi BF.
    Journal: Angew Chem Int Ed Engl; 2013 Dec 16; 52(51):13588-92. PubMed ID: 24174011.
    Abstract:
    Give Me an Ar, give Me an N! Arylation of the methyl group in a simple derivative of readily available alanine under palladium catalysis was followed by intramolecular amidation at the same position to give chiral α-amino-β-lactams with a wide range of aryl substituents (see scheme; Phth=phthaloyl). The α-amino-β-lactams were obtained in moderate to high yields with good functional-group tolerance and high diastereoselectivity.
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