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  • Title: Deaminative and decarboxylative catalytic alkylation of amino acids with ketones.
    Author: Kalutharage N, Yi CS.
    Journal: Angew Chem Int Ed Engl; 2013 Dec 16; 52(51):13651-5. PubMed ID: 24174407.
    Abstract:
    It cuts two ways: The cationic [Ru-H] complex catalyzes selective coupling of α- and β-amino acids with ketones to form α-alkylated ketone products. The reaction involves CC and CN bond cleavage which result in regio- and stereoselective alkylation using amino acids. A broad substrate scope and high functional-group tolerance is demonstrated.
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