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  • Title: Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives.
    Author: Yurttaş L, Duran M, Demirayak Ş, Gençer HK, Tunalı Y.
    Journal: Bioorg Med Chem Lett; 2013 Dec 15; 23(24):6764-8. PubMed ID: 24176398.
    Abstract:
    In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl)thio]-1-(aryl)ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the most effective compounds was established by performing Brine-Shrimp lethality assay. Antifungal activity of the compounds was found to be higher than antibacterial and anticancer activities of the compounds.
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