These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Actions of the slow channel activator, Bay-K-8644, on the electrical activity of 3-day-old embryonic chick hearts.
    Author: Sada H, Sada S, Sperelakis N.
    Journal: Clin Exp Pharmacol Physiol; 1985; 12(5):521-5. PubMed ID: 2417767.
    Abstract:
    In order to assess the effects of Bay-K-8644 on electrical activities of young embryonic chick hearts in which the rising phase of the action potential (AP) depends on tetrodotoxin-insensitive slow Na+ currents, slow AP were recorded in spontaneously beating 3-day-old embryonic chick hearts. Bay-K-8644(10(-6) mol/l) caused increases in the maximum rate of rise, amplitude, and duration of the slow AP; there was a slow increase in the spontaneous firing rate. Thus, Bay-K-8644 stimulates Na+ influx through TTX-insensitive slow channels.
    [Abstract] [Full Text] [Related] [New Search]