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  • Title: Maternal antenatal vitamin D status and offspring muscle development: findings from the Southampton Women's Survey.
    Author: Harvey NC, Moon RJ, Sayer AA, Ntani G, Davies JH, Javaid MK, Robinson SM, Godfrey KM, Inskip HM, Cooper C, Southampton Women's Survey Study Group.
    Journal: J Clin Endocrinol Metab; 2014 Jan; 99(1):330-7. PubMed ID: 24178796.
    Abstract:
    CONTEXT: Maternal 25-hydroxyvitamin D [25(OH)D] status in pregnancy has been associated with offspring bone development and adiposity. Vitamin D has also been implicated in postnatal muscle function, but little is known about a role for antenatal 25(OH)D exposure in programming muscle development. OBJECTIVE: We investigated the associations between maternal plasma 25(OH)D status at 34 weeks of gestation and offspring lean mass and muscle strength at 4 years of age. DESIGN AND SETTING: We studied a prospective UK population-based mother-offspring cohort: the Southampton Women's Survey (SWS). PARTICIPANTS: Initially, 12,583 nonpregnant women were recruited into the SWS, of whom 3159 had singleton pregnancies; 678 mother-child pairs were included in this analysis. MAIN OUTCOMES MEASURED: At 4 years of age, offspring assessments included hand grip strength and whole-body dual-energy x-ray absorptiometry, yielding lean mass and percent lean mass. Physical activity was assessed by 7-day accelerometry in a subset of children (n=326). RESULTS: The maternal serum 25(OH)D concentration in pregnancy was positively associated with offspring height-adjusted hand grip strength (β=0.10 SD/SD, P=.013), which persisted after adjustment for maternal confounding factors, duration of breastfeeding, and child's physical activity at 4 years (β=0.13 SD/SD, P=.014). Maternal 25(OH)D was also positively associated with offspring percent lean mass (β=0.11 SD/SD, P=.006), but not total lean mass (β=0.06 SD/SD, P=.15). However, this association did not persist after adjustment for confounding factors (β=0.09 SD/SD, P=.11). CONCLUSIONS: This observational study suggests that intrauterine exposure to 25(OH)D during late pregnancy might influence offspring muscle development through an effect primarily on muscle strength rather than on muscle mass.
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