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  • Title: Effect of somatostatin and its analogs on histamine-stimulated cAMP production in isolated guinea pig gastric glands.
    Author: Nishihara S, Tanaka A, Yoshida K, Imazono Y, Misawa T, Funakoshi A, Ibayashi H.
    Journal: Gastroenterol Jpn; 1985 Dec; 20(6):543-7. PubMed ID: 2417908.
    Abstract:
    The effect of somatostatin-14 (ss-14), somatostatin-28 (ss-28), and [D-trp8]somatostatin-14 ([ D-trp8]ss-14) on both histamine-stimulated cellular cAMP production and [3H]-cimetidine binding on plasma membranes in isolated guinea pig gastric glands was investigated. These three peptides partially inhibited (approximately 50% maximally) the increase of cAMP production stimulated by histamine. There was no inhibition of [3H]-cimetidine binding on plasma membranes from these isolated gastric glands. These results indicate that somatostatin acts directly on parietal cells and inhibits histamine-stimulated cAMP production with no influence on H2 receptor in histamine stimulated gastric secretion. Inhibitory potency of somatostatin and its analogs against histamine-stimulation may be equal at the cellular level.
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