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  • Title: The role of Langerhans cells and keratinocytes in epidermal immunity.
    Author: Choi KL, Sauder DN.
    Journal: J Leukoc Biol; 1986 Mar; 39(3):343-58. PubMed ID: 2418143.
    Abstract:
    The immunology of the epidermis has received considerable study over recent years. After the antigen-presenting capacity of epidermal Langerhans cells was confirmed, subsequent studies suggested that keratinocytes could modulate certain immunologic events through production of a cytokine, epidermal cell-derived thymocyte-activating factor (ETAF). Most recently, a murine epidermal cell population, the dendritic Thy-1-positive cell, has been shown to possess natural killer-cell-like activity. In this review, the biology of these cell types are discussed. A discussion of allergic contact hypersensitivity and its alteration by ultraviolet light is used to illustrate some of the complex control mechanisms that continue to be the subject of ongoing study.
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