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  • Title: Bioactive eudesmane and germacrane derivatives from Inula wissmanniana Hand.-Mazz.
    Author: Cheng XR, Zhang SD, Wang CH, Ren J, Qin JJ, Tang X, Shen YH, Yan SK, Jin HZ, Zhang WD.
    Journal: Phytochemistry; 2013 Dec; 96():214-22. PubMed ID: 24189347.
    Abstract:
    Phytochemical investigation of Inula wissmanniana Hand.-Mazz. afforded 21 eudesmane and germacrane derivatives, including rare 4,5-secoeudesman-12,5-olide, eudesman-12,5-olide, 3,4-secoeudesman-12-oic acid, and germacra-4-en-12,6-olides. Their structures were elucidated by combinative analyses of MS, NMR, electronic circular dichroism, and X-ray crystallography data. Moreover, most of the isolates exhibited inhibition against lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages and cytotoxicity in HepG2, PC-3, and MGC-803 tumor cells.
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