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  • Title: The effect of different doses of 32P in the treatment of primary thrombocytosis.
    Author: Randi ML, Fabris F, Varotto L, Peverelli P, Girolami A.
    Journal: Folia Haematol Int Mag Klin Morphol Blutforsch; 1985; 112(6):950-6. PubMed ID: 2419226.
    Abstract:
    We report on a follow up in 23 patients with primary thrombocytosis treated with two different doses of 32phosphorus phosphate (32P). Ten patients with essential thrombocytosis (ET) received 2 mCi and 13 patients with polycythemia vera (PV) received the standard dose of 0.1 mCi/kg b.w. The patients were listed as having a complete response (CR), partial response (PR) or no response (NR) considering platelet count at 3 and 12 months after 32P injection. The results indicate the existence of a clear correlation of the rate of remission with the 32P injected dose. PV patients show, in fact, a percentage of complete remission higher than ET patients. However, the use of higher doses induces more early and long-term complications.
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