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  • Title: [Metabolic alkalosis. Compensation mechanisms in the light of new experimental data].
    Author: Randazzo A, Cremonesi G, Martinotti R, Cremonini L, Parziale M, Santambrogio S.
    Journal: Minerva Med; 1975 Oct 17; 66(69):3623-36. PubMed ID: 241948.
    Abstract:
    Changes in arterial blood and erythrocyte acid-base and electrolyte balance in the course of acute alkalinisation caused by bicarbonate loading showed that extracellular alkalosis has no significant effect on the concentration of intraerythrocyte bicarbonate concentration, though a marked increase in pH and electrolyte balance within the red cell is apparent. Erythrocyte alkalinisation may thus be seen as essentially due to the escape of H+ ions, while the entry of Na+ ions is the main device by which the law of electroneutrality is respected. The literature suggests that lactic acid offers a source of H+ ions for destruction of bicarbonate, whereas the diffusion of the ion lactate within the cell is compensated by the release of Cl-. In addition, the data now reported indicate that the red cell is a sufficiently valid model for the study of phenomena occurring within the intracellular compartment when a state of extracellular alkalinisation in created.
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