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Title: Plakinamine M, a steroidal alkaloid from the marine sponge Corticium sp. Author: Lu Z, Koch M, Harper MK, Matainaho TK, Barrows LR, Van Wagoner RM, Ireland CM. Journal: J Nat Prod; 2013 Nov 22; 76(11):2150-2. PubMed ID: 24195491. Abstract: By means of bioassay-guided fractionation, a new steroidal alkaloid, plakinamine M (1), and the known compound, plakinamine L (2), with a unique acyclic side chain, were isolated from the marine sponge Corticium sp. collected from New Britain, Papua New Guinea. The structures were determined on the basis of extensive 1D and 2D NMR and HRESIMS. The two compounds showed inhibition of Mycobacterium tuberculosis with MIC values of 15.8 and 3.6 μg/mL, respectively.[Abstract] [Full Text] [Related] [New Search]