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  • Title: [Microdensitometric research on DNA in the cells of a primary kidney tumor after Spongostan embolization of the renal artery].
    Author: Cylwik B, Darewicz J, Karasewicz B.
    Journal: Z Urol Nephrol; 1985 Dec; 78(12):649-54. PubMed ID: 2420096.
    Abstract:
    In klatsch preparations of renal tumours (light-cellular carcinomas with malignity degree 2 and 3) microdensitometric investigations of the DNA-content were performed. In the 1st group the material came from 10 patients in whom a unique nephrectomy, in the 2nd group from 10 patients in whom 2 days before nephrectomy an embolisation of the renal artery with Spongostan, in the 3rd group from 10 patients in whom 14 days after embolisation the nephrectomy had been performed. From the analysis of the histograms follows that in the cytoblasts of the tumours of the 3rd group the percentage of diploid and paradiploid nuclei is higher than in the groups I and II: deviation to the left of the histogram. However, the index of the mean DNA-content is smaller in the 3rd group than in the 1st and 2nd group, correspondingly: 8.79, 10.52 and 11.8; the difference is statistically significant. The results obtained show that the embolisation of the renal artery may not only lead to a necrosis of the neoplasmatic tissue, but also to an inhibition of the DNA-synthesis in the persisting cancer cells.
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