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  • Title: [Intravenous cibenzoline in the treatment of ventricular and supraventricular arrhythmias].
    Author: Haiat R, Aymard MF, Dufour A.
    Journal: Arch Mal Coeur Vaiss; 1985 Oct; 78 Spec No():95-7. PubMed ID: 2420300.
    Abstract:
    The efficacy of intravenous cibenzoline in the treatment of supraventricular and ventricular arrhythmias was demonstrated in a French trial of 212 patients including 40 in the acute phase of myocardial infarction. The minimal therapeutic plasma concentration was about 0.3 microgram/ml: this was obtained by a loading dose of 1 mg/kg relayed by a perfusion of 8 mg/kg/24 hours. The clinical tolerance was satisfactory in 96.2% of cases when the contra-indications were respected (severe cardiac failure, intraventricular conduction defects and non-paced 2nd and 3rd degree atrioventricular block). Local tolerance was excellent in all cases.
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