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  • Title: The off-label use of the Amplatzer muscular VSD occluder for large patent ductus arteriosus: a case report and review.
    Author: Cubeddu RJ, Babin I, Inglessis I.
    Journal: Cardiovasc Interv Ther; 2014 Jul; 29(3):256-60. PubMed ID: 24203581.
    Abstract:
    A percutaneous approach to the closure of patent ductus arteriosus (PDA) is the preferred procedure in the majority of cases. However, there is little experience with percutaneous closure of unusually large PDA. We report the case of a 28-year-old female with moderate left ventricular dilation and pulmonary hypertension resulting from a large 16 mm PDA. Percutaneous closure was successfully performed using an off-label Amplatzer muscular ventricular septal defect occluder after intravascular ultrasound assessment. Technical challenges, including accurate assessment of defect size and device selection are exemplified along with a comprehensive overview of the available literature.
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