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  • Title: Lymphokines regulate immunoglobulin isotype expression in an antigen-specific immune response.
    Author: Tesch H, Müller W, Rajewsky K.
    Journal: J Immunol; 1986 Apr 15; 136(8):2892-5. PubMed ID: 2420875.
    Abstract:
    The control of immunoglobulin class switching appears to involve T cell-derived lymphokines. Such lymphokines have been shown to affect isotype expression in polyclonally activated B cells. We show in this paper that the same lymphokines similarly control isotype expression in an antigen-specific response acting in concert with a "T cell independent" antigen. In this situation, B cell growth factor II (BCGF II) enhances the production of antigen-specific IgM antibodies, whereas the production of antigen-specific IgG1 antibodies is only observed in the presence of B cell differentiation factor gamma (BCDF gamma). These results suggest that these lymphokines (and perhaps additional ones) are involved in the control of isotype expression in antigen-specific responses.
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