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  • Title: Effects of RF profile on precision of quantitative T2 mapping using dual-echo steady-state acquisition.
    Author: Wu PH, Cheng CC, Wu ML, Chao TC, Chung HW, Huang TY.
    Journal: Magn Reson Imaging; 2014 Jan; 32(1):102-6. PubMed ID: 24211187.
    Abstract:
    The dual echo steady-state (DESS) sequence has been shown successful in achieving fast T2 mapping with good precision. Under-estimation of T2, however, becomes increasingly prominent as the flip angle decreases. In 3D DESS imaging, therefore, the derived T2 values would become a function of the slice location in the presence of non-ideal slice profile of the excitation RF pulse. Furthermore, the pattern of slice-dependent variation in T2 estimates is dependent on the RF pulse waveform. Multi-slice 2D DESS imaging provides better inter-slice consistency, but the signal intensity is subject to integrated effects of within-slice distribution of the actual flip angle. Consequently, T2 measured using 2D DESS is prone to inaccuracy even at the designated flip angle of 90°. In this study, both phantom and human experiments demonstrate the above phenomena in good agreement with model prediction.
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