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  • Title: Ultrastructural effects of recombinant gamma-interferon on cultured human keratinocytes.
    Author: Nickoloff BJ, Mahrle G, Morhenn V.
    Journal: Ultrastruct Pathol; 1986; 10(1):17-21. PubMed ID: 2421470.
    Abstract:
    To extend our initial observations that recombinant gamma-interferon (r gamma IFN) influences the growth and differentiation of normal cultured human keratinocytes, we studied the electron microscopic changes induced by r gamma IFN. Treatment of cultured human keratinocytes with 10(3) units/ml (7.1 nM) of r gamma IFN produced a shift toward an increasing percentage of attached cells that had a mature-type, differentiated appearance rather than a basal type of proliferating cell, as observed in control, untreated cultures. This report extends the number of cell types that can be influenced by r gamma IFN at the ultrastructural level and supports the notion that r gamma IFN can influence both growth and maturation of normal cultured human keratinocytes.
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