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  • Title: [Action of interferons on the reproduction of herpes simplex viruses in in vitro experiments].
    Author: Pokidysheva LN, Temicheva EV.
    Journal: Vopr Virusol; 1986; 31(1):81-3. PubMed ID: 2421486.
    Abstract:
    Tests of various interferon preparations (alpha, alpha2, alpha-beta, beta, and swine leukocyte) in human diploid fibroblast culture for the presence or absence of cytopathic effect of herpes simplex viruses type 1 and 2 (HSV-1 and HSV-2) demonstrated antiviral effect of all interferons with the exception of lymphoblastoid one. Preparations of alpha and swine leukocyte interferons were the most effective for inhibition of HSV-1 reproduction. Recombinant interferon was 10-fold and fibroblast interferon 100-fold less active for HSV-1 than alpha- and swine leukocyte interferons. All the interferons under study (alpha-beta) were similarly active in their antiviral effect on HSV-2 reproduction.
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