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  • Title: A calmodulin dependent Ca2+-activated K+ channel in the adipocyte plasma membrane.
    Author: Pershadsingh HA, Gale RD, Delfert DM, McDonald JM.
    Journal: Biochem Biophys Res Commun; 1986 Mar 28; 135(3):934-41. PubMed ID: 2421725.
    Abstract:
    Increased membrane permeability (conductance) that is specific for K+ and directly activated by Ca2+ ions, has been identified in isolated adipocyte plasma membranes using the K+ analogue, 86Rb+. Activation of these K+ conductance pathways (channels) by free Ca2+ was concentration dependent with a half-maximal effect occurring at 32 +/- 4 nM free Ca2+ (n = 7). Addition of calmodulin further enhanced the Ca2+ activating effect on 86Rb+ uptake (K+ channel activity). Ca2+-dependent 86Rb+ uptake was inhibited by tetraethylammonium ion and low pH. It is concluded that the adipocyte plasma membrane possesses K+ channels that are activated by Ca2+ and amplified by calmodulin.
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