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  • Title: On the mechanism of enhanced release of [14C]glutamate in hippocampal long-term potentiation.
    Author: Lynch MA, Bliss TV.
    Journal: Brain Res; 1986 Mar 26; 369(1-2):405-8. PubMed ID: 2421848.
    Abstract:
    K+-induced release of [14C]glutamate was studied in slices of dentate gyrus prepared from control rats and rats in which long-term potentiation (LTP) had been induced in vivo. At all concentrations of Ca2+ studied, release from potentiated slices was greater than from control slices. In the same preparations both Ruthenium Red and caffeine enhanced basal release but in potentiated tissue the Ruthenium Red-induced release was significantly greater than in control tissue. These results are discussed in the light of our recent finding that enhanced transmitter release is associated with LTP.
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