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  • Title: HPTLC determination of chemical composition variability in raw materials used in botanicals.
    Author: Toniolo C, Nicoletti M, Maggi F, Venditti A.
    Journal: Nat Prod Res; 2014; 28(2):119-26. PubMed ID: 24219430.
    Abstract:
    Besides the chemotaxonomic value, nowadays determination of biodiversity and chemical variability has a commercial impact. The exact identity of raw material and constituents of botanical products, such as food supplements or herbal remedies, is a very important argument, being the real prerequisite for quality control and traceability, followed by the determination of active components. However, the analytical approach must consider the natural great variability in secondary metabolites and product form, such as in extracts. Against the reductive approach, on the basis of single chemical standards, so far dominant in Pharmacopoeias monographs, we report applications and utility of the high-performance thin-layer chromatography fingerprint in determination of species of the same genus, of populations of the same species and of different drugs of the same plant.
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