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  • Title: Genetic variants on 17q21 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population.
    Author: Qiu R, Zhang H, Zhao H, Li J, Guo C, Gong Y, Liu Q.
    Journal: Scand J Rheumatol; 2013; 42(6):469-72. PubMed ID: 24219690.
    Abstract:
    OBJECTIVES: The aim of this study was to test whether orosomucoid like 3 (ORMDL3) and 17q21 variants are associated with susceptibility to ankylosing spondylitis (AS) in a Chinese population. METHOD: A total of 753 unrelated AS patients and 1120 ethnically matched healthy controls were recruited. Seven single nucleotide polymorphisms (SNPs: rs7216389, rs12603332, rs12936231, rs9303277, rs11557467, rs1007654, and rs17608925), which were selected from chromosome 17q21 containing the genes ORMDL3, GSDMB, ZPBP2, and IKZF3, were genotyped by the Taqman SNP genotyping assay. RESULTS: Five of the SNPs (rs7216389, rs12603332, rs12936231, rs9303277, and rs11557467) were associated with AS (all p ≤ 0.01), especially in males (all p < 0.001). Of these, rs7216389, rs12603332, rs12936231, and rs11557467 were strongly associated with severity of the disease based on radiographic findings (p < 0.05). CONCLUSIONS: Our study confirmed that variants in chromosome 17q21 are significantly associated with AS in a Chinese Han population.
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