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  • Title: Osthole inhibits proliferation and induces apoptosis in human osteosarcoma cells.
    Author: Ding Y, Lu X, Hu X, Ma J, Ding H.
    Journal: Int J Clin Pharmacol Ther; 2014 Feb; 52(2):112-7. PubMed ID: 24219966.
    Abstract:
    OBJECTIVE: The purpose of this study was to investigate the effect of osthole on osteosarcoma cell proliferation and apoptosis. METHOD: Cell counting Kit-8 assay was performed to establish the effects of osthole on osteosarcoma MG-63 cell proliferation. Annexin V-FITC/PI was performed to analyze the apoptotic rate of the cells. RESULT: The inhibitory effects of osthole on the expression of BCL-2, BAX, and caspase-3 were detected by Western blotting. Osthole inhibited the growth of human osteosarcoma MG-63 cells by inhibiting cell proliferation and induced cell apoptosis. Western blotting demonstrated that osthole downregulated the expressions of BCL-2 and caspase-3 and upregulated the expression of BAX in human osteosarcoma cells. CONCLUSION: Osthole can inhibit osteosarcoma cell proliferation and induced apoptosis effectively in a dose-dependent manner through downregulating the expression of BCL-2 and caspase-3 proteins levels and upregulating the expression of BAX proteins levels.
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