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  • Title: Effect of anterior hypothalamic deafferentation and continuous growth hormone infusion on the hepatic synthesis of alpha 2u-globulin in the male rat.
    Author: Chatterjee B, Demyan WF, Gustafsson JA, Harris MW, Hökfelt T, Norstedt G, Roy AK.
    Journal: J Endocrinol; 1986 Mar; 108(3):351-5. PubMed ID: 2422309.
    Abstract:
    Anterior hypothalamic deafferentation and infusion of human GH (hGH) in the normal male rat caused a marked reduction in the hepatic concentration of alpha 2u-globulin, an androgen-dependent protein. Although s.c. injections of hGH (twice-daily) resulted in more than a 50% reduction in the hepatic level of alpha 2u-globulin, the same dose of hGH when administered continuously through osmotic minipumps caused a threefold greater inhibition. The decreased hepatic concentration of alpha 2u-globulin after hGH administration was associated with corresponding changes in the hepatic level of translatable alpha 2u-globulin messenger RNA. Continuous infusion of hGH through osmotic minipumps and removal of the anterior hypothalamic influence on GH secretion by deafferentation also caused a marked reduction in the cytoplasmic androgen-binding activity of the rat liver. These results suggest that alterations in the level and pattern of GH secretion may influence hepatic androgen-binding activity and alpha 2u-globulin synthesis.
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