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  • Title: Construction of spiro-fused 2-oxindole/α-methylene- γ-butyrolactone systems with extremely high enantioselectivity via indium-catalyzed amide allylation of N-methyl isatin.
    Author: Murata Y, Takahashi M, Yagishita F, Sakamoto M, Sengoku T, Yoda H.
    Journal: Org Lett; 2013 Dec 20; 15(24):6182-5. PubMed ID: 24224753.
    Abstract:
    A remarkably effective method allowing an extremely high enantioselective synthesis of the spiro-fused 2-oxindole/α-methylene-γ-butyrolactones is described. The key strategy lies in the use of indium-catalyzed asymmetric amide allylation of N-methyl isatin with functionalized allylstannanes, which can lead to the antineoplastic spirocyclic lactones in almost enantiopure forms.
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