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  • Title: Effect of 6-OHDA injected into the locus coeruleus on apomorphine-induced aggression.
    Author: Puciłowski O, Kozak W, Valzelli L.
    Journal: Pharmacol Biochem Behav; 1986 Mar; 24(3):773-5. PubMed ID: 2422669.
    Abstract:
    Bilateral microinjections of 6-hydroxydopamine (6-OHDA) into the nuclei loci coerulei (LC) of male Wistar rats resulted in significant depletion of mesencephalic and striatal norepinephrine, accompanied by a small reduction in dopamine content only in the striatum. Apomorphine (2.5 mg/kg IP) induced marked aggression consisting of prolonged posturing, vocalization and attacks only in 6-OHDA lesioned animals. Biochemical analysis revealed that 6-OHDA antagonized the ability of apomorphine to raise the serotonin concentration in the striatum. It is concluded that the LC neurons play an inhibitory role in apomorphine-induced aggressiveness and the involvement of serotonergic neurons is suggested.
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