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  • Title: Neonatal human foreskin keratinocytes produce 1,25-dihydroxyvitamin D3.
    Author: Bikle DD, Nemanic MK, Whitney JO, Elias PW.
    Journal: Biochemistry; 1986 Apr 08; 25(7):1545-8. PubMed ID: 2423114.
    Abstract:
    Primary cultures of neonatal human foreskin keratinocytes converted 25-hydroxyvitamin D in high yield to a metabolite with the chromatographic behavior of 1,25-dihydroxyvitamin D3. The identity of this metabolite as 1,25-dihydroxyvitamin D3 was confirmed both by its potency in displacing 1,25-dihydroxyvitamin D3 in the chick cytosol receptor assay and by mass spectral analysis. These results suggest that 1,25-dihydroxyvitamin D3 may be formed in the epidermis to regulate vitamin D production by the epidermis and to provide an alternative to 1,25-dihydroxyvitamin D3 production by the kidneys.
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