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  • Title: Radiofrequency ablation after arterial injection of miriplatin-iodized oil suspension into swine liver: ablative zone size and tissue platinum concentration.
    Author: Yamanaka T, Takaki H, Nakatsuka A, Uchida K, Junji U, Fujimori M, Hasegawa T, Yoneda M, Shiraishi T, Sakuma H, Yamakado K.
    Journal: Cardiovasc Intervent Radiol; 2014 Aug; 37(4):1047-52. PubMed ID: 24232037.
    Abstract:
    PURPOSE: To evaluate whether arterial injection of miriplatin-iodized oil suspension facilitates ablative zone expansion by radiofrequency (RF) ablation using a Cool-Tip electrode and to provide effective tissue platinum concentration in the normal swine liver. MATERIALS AND METHODS: RF ablation was performed at three sites of each liver. RF ablation alone was performed in two animals (control). Ablation was performed after arterial injection of iodized oil (iodized-oil group) or a miriplatin-iodized oil suspension (miriplatin group) in two animals each. Long- and short-axis diameters of the ablative zone were measured. In the miriplatin group, tissue platinum concentrations were measured in the ablative, surrounding hyperemic rim, and nonablative zones. RESULTS: The mean long- and short-axis diameters of ablative zones were 27.0 ± 3.1 and 18.0 ± 0.6 mm in the control. Although the long-axis diameter (30.2 ± 2.8 mm, p = 0.07) showed no significant expansion, the short-axis diameter (20.8 ± 2.6 mm, p = 0.04) was significantly expanded more in the iodized-oil group than in the control. Ablative zone sizes were largest in the miriplatin group. The long-axis diameter (33.5 ± 2.4 mm, p = 0.01) was significantly larger than that in the control. The short-axis diameter (27.2 ± 1.9 mm, p = 0.004) was significantly larger than that of the iodized-oil group. Tissue platinum concentrations showed an effective antitumor effect (≥9 μg/g) in ablative (16.5 ± 5.7 μg/g), surrounding hyperemic rim (18.0 ± 5.1 μg/g), and nonablative zones (mean 22.2 ± 5.7 μg/g) (p = 0.21). CONCLUSION: Arterial injection of miriplatin-iodized oil suspension can expand the ablative zone size and provide effective tissue platinum concentration on tumor control in the ablative zones and their surrounding hyperemic rim.
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