These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Are anti-brain antibodies in multiple sclerosis directed to myelin basic protein? Studies employing the Shiverer mouse mutant.
    Author: Ryberg B, Jacque C.
    Journal: Acta Neurol Scand; 1986 Mar; 73(3):247-52. PubMed ID: 2424259.
    Abstract:
    The dysmyelinating mouse mutant Shiverer has a severe and relatively selective deficiency of myelin basic protein (MBP) in the central and peripheral nervous system. Nevertheless, Shiverer brain and control-mouse brain showed similar antigenic titers when tested by a complement fixation assay against a panel of 14 multiple sclerosis (MS) sera and 6 MS CSF samples known to represent several specificities of antibrain antibodies. By analogy with experimental allergic encephalomyelitis, a sensitization to MBP has been proposed in MS. Our results, however, show that antibodies to other CNS antigens are quantitatively more important in this disease.
    [Abstract] [Full Text] [Related] [New Search]