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  • Title: Clinical and biochemical features of depression in Parkinson's disease.
    Author: Mayeux R, Stern Y, Williams JB, Cote L, Frantz A, Dyrenfurth I.
    Journal: Am J Psychiatry; 1986 Jun; 143(6):756-9. PubMed ID: 2424323.
    Abstract:
    Among 49 consecutive patients with Parkinson's disease, 40% were depressed according to DSM-III; they had major depression or dysthymic disorder accompanied by sleep disturbance, fatigue, psychomotor retardation, loss of self-esteem, and excessive guilt. During a 10-day dopamine-free period, lumbar puncture was performed to measure the metabolites of dopamine, serotonin, and norepinephrine. Patients were given an overnight dexamethasone suppression test, and the effects of thyrotropin-releasing hormone and L-dopa on plasma growth hormone and prolactin were examined. Level of CSF 5-hydroxyindoleacetic acid was lowest in parkinsonian patients with major depression and was related to psychomotor retardation and loss of self-esteem.
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