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  • Title: Effect of sustained exercise on concentrations of plasma aromatic and branched-chain amino acids and brain amines.
    Author: Acworth I, Nicholass J, Morgan B, Newsholme EA.
    Journal: Biochem Biophys Res Commun; 1986 May 29; 137(1):149-53. PubMed ID: 2424444.
    Abstract:
    In both trained and untrained rats, exercise increased the plasma concentration ratio of aromatic amino acids to branched-chain amino acids which might favour entry of the aromatic amino acids into the brain. Exercise in trained rats did not change the brain concentration of 5-hydroxytryptamine but increased that of 5-hydroxyindole acetic acid. Exercise in the untrained rat increased the concentration of brain tryptophan and that of 5-hydroxytryptamine but that of 5-hydroxyindole acetic acid was unchanged. The increased concentration of 5-hydroxytryptamine in untrained rats might be involved in central fatigue.
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