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  • Title: Triiodothyronine receptor sites in serum-free cultured hepatocytes from adult rat liver.
    Author: Goglia F, Gallo G, Palmero S, Voci A, Fugassa E.
    Journal: Cell Biochem Funct; 1985 Apr; 3(2):91-4. PubMed ID: 2424630.
    Abstract:
    Nuclear T3 specific binding sites were characterized by Scatchard analyses of L-125I-T3 binding to nuclei extracted from freshly isolated and 1, 2 and 6 day-cultured hepatocytes. The results demonstrate a marked decrease in T3 binding capacity of nuclei extracted from 1 day-cultured cells followed by an almost complete recovery within 6 days. The affinity constant value of nuclear receptor sites is significantly decreased in 1 day-cultured cells with a subsequent partial recovery. The affinity and capacity pattern of nuclear T3 binding sites appears to be in line with the delayed responses of hepatocyte primary cultures to T3.
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