These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Methylenedioxymethamphetamine: a potentially neurotoxic amphetamine analogue.
    Author: Schmidt CJ, Wu L, Lovenberg W.
    Journal: Eur J Pharmacol; 1986 May 13; 124(1-2):175-8. PubMed ID: 2424776.
    Abstract:
    The amphetamine analogue, methylenedioxymethamphetamine (MDMA) has received considerable attention recently as a novel and increasingly popular psychoactive agent. When administered acutely to rats in high doses, MDMA caused a selective and dramatic decrease in brain concentrations of serotonin and its metabolite, 5-hydroxyindoleacetic acid. The depletion of serotonin and its metabolite persisted for up to at least one week after a single injection of MDMA at approximately four to five times the acute dose reported for humans. These results are discussed in terms of the possible neurotoxic effects of MDMA.
    [Abstract] [Full Text] [Related] [New Search]