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  • Title: A polypeptide toxin from the coral Goniopora. Purification and action on Ca2+ channels.
    Author: Qar J, Schweitz H, Schmid A, Lazdunski M.
    Journal: FEBS Lett; 1986 Jul 07; 202(2):331-6. PubMed ID: 2424789.
    Abstract:
    A polypeptide toxin has been isolated from Goniopora coral with an Mr of 19 000. Goniopora toxin has the following properties: it induces contraction of guinea pig ileum and this contraction is prevented by Ca2+-channel blockers; it stimulates 45Ca2+ influx in cardiac cells in culture and this stimulation is abolished by Ca2+-channel blockers; it prevents binding of (+)-[3H]PN 200-110 to the Ca2+-channel protein of skeletal muscle T-tubule membranes. All these results taken together suggest that Goniopora toxin is a Ca2+-channel activator.
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