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  • Title: Nerve repair and axonal transport. Distribution of axonally transported proteins during maturation period in regenerating rabbit hypoglossal nerve.
    Author: Danielsen N, Lundborg G, Frizell M.
    Journal: J Neurol Sci; 1986 May; 73(3):269-77. PubMed ID: 2425055.
    Abstract:
    The distribution of fast migrating [3H]leucine-labelled proteins was studied in transected and repaired rabbit hypoglossal nerves. The nerves were repaired 90 days earlier with mesothelial chamber or epineurial suture technique. Fast migrating radiolabelled proteins were transported into the distal nerve segment and neurophysiological recordings from the tongue as well as the presence of myelinated axons in the distal nerve segment verified successful regeneration. The total amount of radioactivity was increased in repaired nerves as compared to contralateral nerves. In both groups there was a significant accumulation of radiolabelled proteins at the site of lesion. Nerves repaired with mesothelial chambers showed significantly more radioactivity in the distal nerve segment as compared to sutured nerves. The present study indicates long-standing effects on axonal transport system after both types of nerve repair. It is our opinion that axonal transport studies are a valuable complement when evaluating experimental nerve repair.
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