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  • Title: [Antibacterial activity of a number of preparations and their combination with a proteolytic enzyme against the microflora of burn and surgical wounds].
    Author: Murashko SN, Moroz AF, Brodinova NS.
    Journal: Antibiot Med Biotekhnol; 1986 May; 31(5):381-4. PubMed ID: 2425729.
    Abstract:
    Antibacterial activity of antibiotics (azlocillin, tobramycin and piperacillin), antiseptics (metacid, chlorhexidine and quinosoline) and some other drugs (dioxidine and mafenide acetate) against the main representatives of the burn and surgical wound microflora, i. e. Staphylococcus, P. aeruginosa, Proteus, Providencia, Serratia, Klebsiella and E. coli was studied. Tobramycin and piperacillin were highly active against P. aeruginosa, Staphylococcus and Proteus. It was shown that in the presence of terrilytin, a proteolytic enzyme the activity of the combinations of chlorhexidine with dioxidine or mafenide acetate against all microorganisms occurring in burn and surgical wounds markedly increased.
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