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  • Title: Antimuscarinic effects of chloroquine in rat pancreatic acini.
    Author: Habara Y, Williams JA, Hootman SR.
    Journal: Biochem Biophys Res Commun; 1986 Jun 13; 137(2):664-9. PubMed ID: 2425800.
    Abstract:
    Chloroquine inhibited carbachol-induced amylase release in a dose-dependent fashion in rat pancreatic acini; cholecystokinin- and bombesin-induced secretory responses were almost unchanged by the antimalarial drug. The inhibition of carbachol-induced amylase release by chloroquine was competitive in nature with a Ki of 11.7 microM. Chloroquine also inhibited [3H]N-methylscopolamine binding to acinar muscarinic receptors. The IC50 for chloroquine inhibition of [3H]N-methylscopolamine binding was lower than that for carbachol or the other antimalarial drugs, quinine and quinidine. These results demonstrate that chloroquine is a muscarinic receptor antagonist in the exocrine pancreas.
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