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  • Title: Differences in anionic dependence of the synaptic efflux of D-aspartic acid and gamma-aminobutyric acid.
    Author: Naalsund LU, Fonnum F.
    Journal: J Neurochem; 1986 Sep; 47(3):687-90. PubMed ID: 2426406.
    Abstract:
    The synaptosomal effluxes of D-aspartate and gamma-aminobutyric acid (GABA) induced by a substitution of the Cl- ions with propionate in the incubation medium were measured in preparations of hippocampal tissue homogenates. The efflux of aspartate was significantly higher than spontaneous efflux at 125 mM Cl- (normal = 144 mM) and was increased with decreasing Cl- concentration. GABA efflux was much less sensitive to a reduction in Cl- concentration than D-aspartate. The efflux was Ca2+-dependent in both cases.
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