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  • Title: Endodermal sinus tumor of the ovary associated with pregnancy.
    Author: Malone JM, Gershenson DM, Creasy RK, Kavanagh JJ, Silva EG, Stringer CA.
    Journal: Obstet Gynecol; 1986 Sep; 68(3 Suppl):86S-89S. PubMed ID: 2426643.
    Abstract:
    The association of endodermal sinus tumor of the ovary with pregnancy is a rare event. Reported is a patient with stage Ic endodermal sinus tumor diagnosed in the 25th week of gestation. She received two cycles of combination chemotherapy consisting of vinblastine, bleomycin, and cisplatin, and delivered a healthy male infant by cesarean section at 32 weeks' gestation. She subsequently completed three more cycles of chemotherapy and remains alive and well. This is the first reported case of a patient with endodermal sinus tumor treated with combination chemotherapy during pregnancy that had a successful outcome for both mother and infant. The literature concerning the association of endodermal sinus tumor and pregnancy and the use of chemotherapy during pregnancy is reviewed.
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