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  • Title: Measurement of single channel currents from cardiac gap junctions.
    Author: Veenstra RD, DeHaan RL.
    Journal: Science; 1986 Aug 29; 233(4767):972-4. PubMed ID: 2426781.
    Abstract:
    Cardiac gap junctions consist of arrays of integral membrane proteins joined across the intercellular cleft at points of cell-to-cell contact. These junctional proteins are thought to form pores through which ions can diffuse from cytosol to cytosol. By monitoring whole-cell currents in pairs of embryonic heart cells with two independent patch-clamp circuits, the properties of single gap junction channels have been investigated. These channels had a conductance of about 165 picosiemens and underwent spontaneous openings and closings that were independent of voltage. Channel activity and macroscopic junctional conductance were both decreased by the uncoupling agent 1-octanol.
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