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  • Title: [Relations of fetuin-A with estimated glomerular filtration rate and carotid artery calcification in patients with chronic kidney disease].
    Author: Zhan J, Liang J, Wang Z.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2013 Nov; 33(11):1689-91. PubMed ID: 24273280.
    Abstract:
    OBJECTIVE: To investigate the association of fetuin-A with residual renal function and carotid artery calcification in patients with chronic kidney disease (CKD). METHODS: Blood examples were collected form 60 CKD patients in stages CKD3 to CKD5 (20 patients per stage) for measurement of serum fetuin-A, albumin, calcium, phosphorus and parathyroid hormone, cholesterol, triglycercide, low-density lipoprotein, and high-density lipoprotein. MDRD equation was used to calculate the estimated glomerular filtration rate (eGFR), and ELISA was used to detect serum fetuin-A. Color Doppler ultrasound was performed to measure carotid intima-media thickness (CIMT). RESULTS: As the eGFR decreased, serum fetuin-A significantly decreased in CKD5 stage compared with that in CKD4 stage (P<0.05); compared with that in CKD3 stage, serum fetuin-A level was significantly lowered in CKD4 stage (P<0.05). Linear regression analysis suggested a significant positive correlation between fetuin-A and eGFR. The rate of carotid artery calcification was the highest in CKD5 stage. Rank correlation analysis showed a negative correlation between fetuin-A and cIMT, and logistic regression analysis identified decreased serum Fetuin-A as a risk factor of carotid artery calcification. CONCLUSION: Serum fetuin-A decreases following the decrease in eGFR, and decreased serum Fetuin-A level is a risk factor of carotid artery calcification in CKD patients.
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