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  • Title: Potentiation of pressor responses to serotonin by ketamine in isolated perfused rat mesentery.
    Author: Fukuda S, Su C, Lee TJ.
    Journal: J Cardiovasc Pharmacol; 1986; 8(4):765-70. PubMed ID: 2427816.
    Abstract:
    The effects of ketamine on vasoconstrictor responses to periarterial sympathetic nerve stimulation (PNS), norepinephrine (NE), and 5-hydroxytryptamine (5-HT) were studied in normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). The isolated mesenteric arteries were perfused at a constant rate (5 ml/min), and the perfusion pressure was recorded. The pressor responses to PNS (8 Hz, 2 ms, 30 s) were augmented by ketamine (2 X 10(-5) and 10(-4) M) in WKY and SHR. Those to intraarterially infused NE (3 X 10(-10) M) were statistically unaltered. However, in three of seven arterial preparations from WKY and in six of nine preparations from SHR, ketamine (2 X 10(-5) and 10(-4) M) decreased the pressor responses to NE. In contrast, the responses to intraarterial 5-HT (1.3 X 10(-9) mol) were potentiated by ketamine (2 X 10(-5) and 10(-4) M) in SHR and WKY--to a much greater extent in SHR. Fractional release of tritium by PNS from isolated mesenteric arteries previously labeled with 1-[7,8-(3)H]NE (10(-7) M) was unaltered by ketamine (10(-4) M) in SHR and WKY. Cocaine (10(-5) M) prevented the ketamine-induced potentiation of PNS and 5-HT responses. Ketamine as well as cocaine inhibited the accumulations of [3H]5-HT and [3H]NE in intact mesenteric arteries from SHR and WKY to a comparable extent. In tissues denervated by 6-hydroxydopamine, the accumulation of 5-HT was about 70% (WKY) and 60% (SHR) of those in intact tissues, whereas that of NE was about 11% (WKY) and 9% (SHR).(ABSTRACT TRUNCATED AT 250 WORDS)
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