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  • Title: MALDI imaging mass spectrometry in glomerulonephritis: feasibility study.
    Author: Mainini V, Pagni F, Ferrario F, Pieruzzi F, Grasso M, Stella A, Cattoretti G, Magni F.
    Journal: Histopathology; 2014 May; 64(6):901-6. PubMed ID: 24279679.
    Abstract:
    AIMS: The in-situ proteomics technology known as matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) is a powerful technique that combines traditional histology and proteomics. METHODS AND RESULTS: MALDI-IMS was applied to routine diagnostic kidney biopsies in a small group of cases of membranous glomerulonephritis and minimal change disease. Molecular changes were observed not only in the tissue areas with pathological alterations, but also in morphologically normal-looking tissue, highlighting the potential feasibility of using MALDI-IMS as a tool in nephropathology. CONCLUSIONS: This technology can be applied to any biopsy where a frozen section is obtained as part of the diagnostic process. Although we do not yet know the molecular identity of the differentially expressed proteins/peptides, they could represent powerful classifiers of nosological groups.
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