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  • Title: Immunological similarities between an experimental autoimmune myasthenia gravis model and human myasthenia gravis.
    Author: Souan ML, Geffard M.
    Journal: Neurosci Lett; 1986 Aug 04; 68(3):282-7. PubMed ID: 2427976.
    Abstract:
    The induction of experimental autoimmune myasthenia gravis (EAMG) in rabbits after immunization with an acetylcholine (ACh) conjugate was found to possess immunological similarities with human myasthenia gravis. Anti-ACh antibodies, present in human sera, recognized the antigenic determinant, glutarylcholine, used to raise anti-ACh antibodies in rabbits. Identification of anti-anti-ACh antibodies in MG patients enabled us to test for recognition of the anti-ACh antibodies present in rabbit sera. The reverse, the recognition of rabbit auto-anti-anti-ACh antibodies by human anti-ACh antibodies was also tested and found to be specific.
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