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  • Title: [Sudden unexpected death in epilepsy: SUDEP].
    Author: Lamberts RJ, Tan HL, Leijten QH, Sander JW, Thijs RD.
    Journal: Ned Tijdschr Geneeskd; 2013; 157(48):A6193. PubMed ID: 24279949.
    Abstract:
    Sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death. Patients with refractory epilepsy are at especially high risk of SUDEP. SUDEP occurs predominantly at night and unwitnessed, and can best be regarded as a fatal tonic-clonic seizure. While its pathophysiology is incompletely understood, SUDEP is most probably triggered by a number of predisposing and precipitating factors, including seizure-induced respiratory depression and cardiac arrhythmia. Achieving seizure freedom is the best way to prevent SUDEP. Nocturnal supervision may be another alternative preventive strategy, but this requires further research.
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