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  • Title: BASHD-J-resolved-HMBC, an efficient method for measuring proton-proton and heteronuclear long-range coupling constants.
    Author: Furihata K, Tashiro M.
    Journal: Magn Reson Chem; 2014; 52(1-2):27-31. PubMed ID: 24282023.
    Abstract:
    Natural products often possess various spin systems consisting of a methine group directly bonded to a methyl group (e.g. -CHa-CHb(CH3)-CHc-). The methine proton Hb splits into a broadened multiplet by coupling with several vicinal protons, rendering analysis difficult of (n)JC-H with respect to Hb in the J-resolved HMBC-1. In purpose of the reliable and easy measurements of (n)JC-H and (n)JH-H in the aforesaid spin system, we have developed a new technique, named BASHD-J-resolved-HMBC. This method incorporates band selective homo decoupled pulse and J-scaling pulse into HMBC. In this method, high resolution cross peaks can be observed along the F1 axis by J-scaling pulse, and band selective homo decoupled pulse simplified multiplet signals. Determinations of (n)JC-H and (n)JH-H of multiplet signals can easily be performed using the proposed pulse sequence.
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