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  • Title: Preliminary studies of a novel cyclopentadienyl tricarbonyl technetium-99m fatty acid derivative for myocardical imaging.
    Author: Zeng H, Zhang H, Wu X, Chao F, Yu G, Zhang L, Jiang H, Liu H, Hou H, Zhan H, Zhang H, Tian M.
    Journal: J Labelled Comp Radiopharm; 2013 Jan; 56(1):1-5. PubMed ID: 24285133.
    Abstract:
    This study reports the synthesis and evaluation studies of 6'-cyclopentadienyl tricarbonyl technetium-99m 6'-oxo-11-(hexanamide)undecanoic acid (1). 1 was prepared with 26.5 ± 4.3% of radiochemical yield and more than 98% of radiochemical purity. Tissue distribution in mice showed that high radioactivity accumulated in the heart with moderate clearance. However, unfortunately, similar to those of other technetium-labeled fatty acid analogs, the biodistribution studies of 1 in mice showed poor heart-to-blood ratios, which suggested that 1 cannot be used as myocardial imaging agent, and it may provide a theoretical basis or a lab experience for corresponding fatty acid tracers studies.
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