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  • Title: Castleman's disease and primary effusion lymphoma in a HIV-positive patient.
    Author: Scott MJ, Alhariri BC, Farghaly H, Perez R, Arnold FW.
    Journal: Int J STD AIDS; 2014 May; 25(6):455-7. PubMed ID: 24287026.
    Abstract:
    We present a case of primary effusion lymphoma (PEL) occurring simultaneously with Castleman's disease in the same patient. Castleman's disease is distinct from PEL, although both are associated with HHV-8. Other cases have debated whether the coexistence of PEL and Castleman's disease is a recurrence of an original PEL tumour in an extracavitary site, or a secondary HHV-8-associated lymphoma distinct from primary PEL. Our case, along with those described previously, show that co-occurrence of PEL and Castleman's disease is possible and plausible. PEL needs to be included in the differential diagnosis in any HIV-positive patient who presents with a pleural effusion, and diagnosis requires only a simple thoracentesis and appropriate immunohistochemistry.
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