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  • Title: Long-term outcome of endoscopic resection of superficial adenocarcinoma of the esophagogastric junction.
    Author: Yamada M, Oda I, Nonaka S, Suzuki H, Yoshinaga S, Taniguchi H, Sekine S, Kushima R, Saito Y, Gotoda T.
    Journal: Endoscopy; 2013 Dec; 45(12):992-6. PubMed ID: 24288219.
    Abstract:
    BACKGROUND AND STUDY AIM: Endoscopic resection has been favored for the management of intramucosal adenocarcinoma of the esophagogastric junction (AEGJ) over standard treatment with surgical resection. Several previous studies have reported only short-term outcomes. The aim of the present study was to report the long-term follow-up and outcomes of endoscopic submucosal dissection (ESD), a representative endoscopic resection method, for the management of superficial AEGJ. PATIENTS AND METHODS: A retrospective cohort study included 53 consecutive patients with superficial AEGJ who underwent ESD between 2001 and 2007 at the National Cancer Center Hospital, Tokyo, Japan. Rates of overall survival, recurrence-free survival, and cause-specific survival of patients with AEGJ after endoscopic resection were analyzed. RESULTS: The 5-year overall, recurrence-free, and cause-specific survival rates in the 53 patients were 94.2%, 92.3% and 96.1%, respectively. The median follow-up was 6.1 years. En bloc, R0, and curative resection rates were 100 %, 79 %, 68 %, respectively. In 36 patients with curative resection, the cause-specific survival rate was 100 % and no recurrence or metastases were detected. In 17 patients with non-curative resection, recurrence was found in three patients (17 %); two of the three patients died of their disease whilst one patient received chemotherapy. CONCLUSIONS: Superficial AEGJ can be well controlled by ESD when curative resection is achieved.
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