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  • Title: Selective removal of keratan sulfate in chondroitin sulfate samples by sequential precipitation with ethanol.
    Author: Galeotti F, Maccari F, Volpi N.
    Journal: Anal Biochem; 2014 Mar 01; 448():113-5. PubMed ID: 24291704.
    Abstract:
    Keratan sulfate (KS) is present as a contaminant in chondroitin sulfate (CS) mainly extracted from shark cartilage. We report a selective removal procedure of KS in CS samples by means of sequential precipitation with ethanol. Purified shark CS containing approximately 10% to 15% KS was subjected to a precipitation procedure in the presence of increasing percentages of saturated ethanol. In contrast to other solvents, 1.0 volume of ethanol was able to selectively purify CS, with a purity of approximately 100%, from KS. The current selective and simple procedure appears to be a reliable industrial preparation of CS devoid of large amounts of the residual KS.
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